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KMID : 0358819890160030433
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1989 Volume.16 No. 3 p.433 ~ p.441
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THE EFFECT OF THE CALCIUM ANTAGONISTS ON THE SURVIVAL OF THE SKIN FLAPS IN RATS
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Abstract
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Skin flap necrosis can be a catastrophe in reconstructive surgery.
Many attempts have been made clinically and experimentally to improve the survival in random pattern flaps.
As the delay phenomenon theory, that is, vascular smooth muscle relaxation augments the blood flow to the capillary bed of the skin flap, experimental study using the Sprague-Dawley rats performed with the calcium antagonists which cause the dilatation of vascular smooth muscle by blocking the calcium influx into the cells.
Total 100 rats were grouped into control group(10) and 3 experimental groups.
Each experimental group was subdivided into pre-operation, post-operation and pre-operation & post-operation group in accordance with the injection period of calcium antagonists, nifedipine and diltiazem.
All the experimental groups increased the surviving skin flap area than the control group. This suggests that sustained vasodilatation by the calcium antagonists is a major factor of flap survival increment.
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KEYWORD
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